Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6.

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Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6

IL-1 is known to have a central role in the induction of acute-phase response, and some of its activities (including induction of some acute-phase proteins) were reported to be mediated by an induction of IL-6. Administration to rats of 200 ng of human rIL-1 by intracerebroventricular injection resulted in a more marked induction of circulating IL-6 than the same dose of IL-1 administered syste...

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Interleukin-1 induces interleukin-6 production in peripheral blood monocytes.

Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor. Some of these signals induce IL-6 effectively only in one cell type, and this selectivity of induct...

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Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer.

BACKGROUND Previous studies that were based primarily on small numbers of patients suggested that certain circulating proinflammatory cytokines may be associated with lung cancer; however, large independent studies are lacking. METHODS Associations between serum interleukin 6 (IL-6) and interleukin 8 (IL-8) levels and lung cancer were analyzed among 270 case patients and 296 control subjects ...

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Interleukin-6, interleukin-1 beta and interleukin-1 receptor antagonist levels in epileptic seizures

PURPOSE Data are accumulating to support the involvement of inflammatory mechanisms in the pathogenesis and course of epilepsy. METHODS The aim of this study was to examine seizure-induced changes in plasma concentrations of interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1Ra), and interleukin-1 beta (IL-1β) in 23 patients with epilepsy undergoing a video-electroencephalography (E...

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High levels of circulating interleukin-10 in diabetic nephropathy patients.

AIMS The aim of our study was to analyse the level of circulating interleukin-10 (IL-10) and relate it to the grade of albuminuria in patients with diabetic nephropathy (DN) due to type 1 diabetes mellitus (DM). Since IL-10 has met the criteria for an anti-inflammatory and an immunosuppressive cytokine, its activity may be important for clinical outcome of DN. METHODS The IL-10 level was meas...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1990

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.171.5.1773